The Germany international has set his sights on glory in European club football's elite competition, but admitted that the Spanish title is out of their reach
The Santiago Bernabeu side are trailing arch rivals Barcelona by 16 points at the moment, but Khedira is adamant that they can still win silverware this season.
"Winning La Liga is impossible. However, we are third and our aim has to be to get second," Khedira was quoted as saying on the DFB website.
"And we are in the semi-finals of the Copa del Rey and still in the Champions League.
"The dream of all the fans is to win the tenth, the 'decima', and we'll do everything we can to achieve it. And we have a good chance.
"However, it will only be possible if we recover our confidence in La Liga. That is still an important competition."
Real Madrid meet Manchester United in the Champions League round of 16.