Having defeated them already 3-1 earlier in the group stage, the 65-year-old is optimistic the Amsterdam giants can repeat their heroics from a fortnight ago and beat the English champions a second time.
"It's simple, you play to win," Cruyff told De Telegraaf. "In the event of a draw, you still risk losing and it will be very difficult regardless.
|6/1||Ajax are 6/1 with bet365 to win away at Manchester City|
And according to Cruyff, the Eredivisie holders already have the momentum, saying: "There are many less chances [for Ajax] to make mistakes. Attacking teams are often set for trouble after November."