The playmaker says his side are capable of doing the double over the Gunners after beating them at the Emirates in their first meetingLewis Holtby says Schalke are wary of a backlash from Arsenal after "stealing" three points off the Premier League outfit.
The Gelsenkirchen club stunned the Emirates by beating Arsene Wenger's men 2-0 on October 24, to leave Holtby and his team-mates a point above the Gunners at the top of Group B.
"I think that Arsenal are a little bit resentful about us stealing three points on their home territory. But we are wary and well-prepared," the 22-year-old told the club's official website.
"We only concentrate on tomorrow. The form of the day could be a deciding factor, one mistake can immediately be punished," he continued.
The talented midfielder, who has been linked with a move to a number of Premier League clubs, also believes that home advantage could be crucial and urged his side to make the most of it.
"It will be a very good game I think," he continued.
"The thing [Veltins-Arena] will be sold-out and at the moment we are still table-toppers [in Group B], so we have to light the fire from the beginning and show [Arsenal] that we are the landlords. Then we will see the result."