The young left-back comes in for the injured Per Mertesacker, while Thierry Henry is on the bench for his last game before returning to the New York Red Bulls after his loan
The 22-year-old left-back slots into the defence with Thomas Vermaelen moving into the centre to partner Laurent Koscielny in the German's absence.
Club legend Thierry Henry starts on the bench again for what may be his final game in a Gunners shirt, his loan deal from the New York Red Bulls set to expire after this match.
Kevin-Prince Boateng is back for the home side for the first time since suffering a muscular problem in January's derby loss to Inter.
Zlatan Ibrahimovic and Robinho are the illustrious front line for Massimiliano Allegri's men at San Siro, with Milan only fielding six substitutes.
AC Milan starting XI: Abbiati; Abate, Mexes, Thiago Silva, Antonini; Van Bommel, Seedorf, Nocerino; Boateng; Ibrahimovic, Robinho
Subs: Amelia, Nesta, Bonera, Ambrosini, Emanuelson, Pato
Arsenal starting XI: Szczesny; Sagna, Vermaelen, Koscielny, Gibbs; Arteta, Ramsey, Song; Walcott, RVP, Rosicky.
Subs: Fabianski, Djourou, Benayoun, Coquelin, Henry, Oxlade-Chamberlain, Arshavin
More to follow...