Ange Postecoglou wants Monday's farewell friendly to serve as a morale booster for Australia before they head to the World Cup, and the Socceroos coach could well get his wish, as a weakened Bafana Bafana prepare to arrive in Sydney.
The opponents for next's week match at ANZ Stadium have been hit by numerous high-profile withdrawals days before their scheduled departure.
Mile Jedinak's Crystal Palace team-mate Kagisho Dikgacoi will not be involved due a calf issue, while Siyanda Xulu (ankle) of FC Rostov in Russia is also out.
"I can't give any details right now," coach Gordon Igesund was quoted as telling IOL Sport on Monday.
"We are trying to solve the problem and we'll be in a position to give details of the situation at a media conference at Orlando Stadium on Tuesday morning."
Premier Soccer League heavyweights Kaizer Chiefs have flagged the likely absence of Itumeleng Khune, Bernard Parker and Siphiwe Tshabalala.
"All three of our players will go for surgery," Chiefs coach Stuart Baxter said on Monday.
"Parker's knee looks like he should not be playing. We gave them painkillers in our last matches. We have spoken to Igesund and their technical team and he understands the situation.
"Look, it's the doctors who made these decisions not the coaches. We have always supported Bafana by making our players available whenever they were needed."
A number of Orlando Pirates players are also understood to be in doubt. South Africa also have a friendly scheduled against New Zealand on May 30. But with neither game taking place on a FIFA-sanctioned international match window, club sides are not obliged to release their players for national team duty.
While the South African media consider the situation to be drastic, Igesund refused to discuss the details.
"I can't mention their names at the moment as I'm still looking for replacements," the 57-year-old former South Africa international said.
"I have about seven players reported to be injured and they will undergo medical test tomorrow.
"I have been in this situation before and survived.
"I'm hopeful I will get the right players for those who are injured."