Kagisho Dikgacoi will be involved in the London Derby this weekend as Crystal Palace host log leaders Chelsea on Saturday afternoon. The South African midfielder is expected to start once again following his good display at Newcastle United last weekend.
However, he will have to be mentaly and physically prepared for the battle against the likes Nemanja Matic and Frank Lampard in the middle of the park. This could be a defining moment for 'KG' and his teammates to dent Chelsea's title hopes, while at the same time enhancing their chances of surviving relegation.
Steven Pienaar will continue to watch from the stands when Everton take on Fulham at the Craven Cottage on Sunday afternoon as he's still out with a knee injury.
The Merseyside club haven't lost hope on their dream to play European football next season, and getting maximum points in London could get them back in the mix with less than eight games to go.
In the Championship, Tokelo Rantie's AFC Bournemouth are favourites to take all three points against Birmingham City on Saturday. The former Malmo forward is unlikey to start, though he came on as a late subsititute during their emphatic 4-1 win over Leeds United earlier this week.
Rantie's teammate and countryman Andrew Surman is expected to keep his place in the midfield having done well throughout the season. He is one of the most experienced players in the current Bournemouth team.
Struggling Doncaster Rovers side will be looking to bounce back from their disappointing midweek result when they hit the road to face Leeds United in a league encounter on Saturday.
Dean Furman, who came in late against second placed Burnley, is expected to make the bench for Rovers, who are only eight points above the relegation zone. Bongani Khumalo is still out injured.
Kamohelo Mokotjo is expected to feature when PEC Zwolle face ADO Dan Haag on Sunday afternoon. The South African player has just returned from a long term injury, and he is eager to help his side finish in a respectable position on the log.
He will also be bouyed by the fact that Zwolle will be playing in the Dutch Cup final next month, while also looking to impress they prepare for the possibilty of playing in the Europa League next season should they win the Dutch Cup.
Zwolle have certainly improved since Mokotjo's return, and the former SuperSport United man is not willing to put his foot off the pedal. He's one of the rising stars of South African football currently plying their trades abroad.
Thulani Serero returns to action this weekend and he's certain of his place in the starting line-up when Ajax Amsterdam square off against FC Twente on Sunday afternoon.
Amsterdam look set to defend their league title and they are also a game away from reaching the Dutch Cup final where Serero could face his countryman Mokotjo for the first time in a Cup final.
May Mahlangu and Mark Mayambela begin their league campaign with their respective club's weekend after being knocked out of the Swedish Cup in recent weeks.
Mahlangu's IFK Gotenborg will be away to Helsingborg on Monday night. This clash will also mark Mahlangu's first league game since leaving Helsingborg late last year.
Mayambela, formerly with Orlando Pirates and Mpumalanga Black Aces in South Africa, is expected to continue to adapt to his new life in Sweden although he could be given a run when Djurgardens host AIK on Sunday.
Siyanda Xulu could return to FC Rostov's starting line-up this weekend, as the Russian Premier League outfit take on giants Rubin Kazan in a league encounter on Sunday afternoon.
The Bafana defender sat on the bench in last weekend's 3-3 draw, but his absence was hugely missed as Rostov went on to concede three goals, squadering their lead on two separate occasions.