Kagisho Dikgacoi's Crystal Palace will be looking for their first Premier League victory in 23 years over champions Manchester United on Saturday afternoon.
The Eagles have moved away from the relegation zone, but they still need results against David Moyes' side. Dikgacoi will be hoping for another start against the Red Devils having played against Arsenal already this season.
Steven Pienaar will travel with Everton to Stamford Bridge to face Chelsea at lunch time on Saturday.
Chelsea are unbeaten at home in the league under Jose Mourinho since 2004, and Everton players will need to be at their ultimate best if they are to break that record.
In the Championship, Tokelo Rantie will look to add to his tally of goals this season when AFC Bournemouth face Derby County at The iPro Stadium on Saturday.
Rantie netted for the Cherries last weekend, and he will be more motivated to find the back of the net again this weekend especially with the Brazil game a few weeks from now.
Rantie's teammate Andrew Surman will be hoping to return to the starting line-up after missing last week's 1-1 draw at home against Burnley.
Bongani Khumalo and Dean Furman are both expected to be in the starting eleven when Doncaster Rovers play Yeovil Town on Saturday afternoon.
Khumalo has been one of the important members of Rovers team this season, and that has left their manager with no option but to field him almost every single game.
Furman also did well to crack the nod this week, but the South African midfielder has often struggled to make the starting line-up this season.
Ayanda Patosi's KSC Lokeren will be looking to return to winning ways at the expense of Anderlecht when the two sides meet on Friday night.
Patosi, who was introduced in the last 12 minutes of Lokeren's 1-1 draw against KAA Gent last weekend, will be hoping to get another chance to impress and build his confidence ahead of Bafana's clash against Brazil on March 5.
Darren Keet hasn't been at his best this season, but the South African goalkeeper will be hoping to keep his place in the starting line-up when KV Kortrijk host RAEC Bergen Mons on Saturday evening.
Keet conceded three goals last weekend, and has only kept one clean sheet since the beginning of the year.
Andile Jali's KV Oostende will also be in action this weekend, hosting Lierse SK, and the Bafana midfielder is expected to get some game time after missing his team's previous encounter.
Like Patosi, Jali is in Gordon Igesund's squad to face Brazil next month, and the games will definitely be good for his fitness leading up to that mouth-watering international clash.
Anele Ngcongca will once again lead Racing Genk at home against Waasland-Beveren on Sunday night.
The Genk full-back is most likely to start for South Africa against the five-time World Champions, as he has consistently done well for the Belgian side this season.
Thulani Serero, back in the Bafana team, will be expected to shine when Ajax Amsterdam clash with AZ Alkmaar on Sunday.
Kamohelo Mokotjo's PEC Zwolle will welcome SC Heracles Almelo on Saturday afternoon, but the former SuperSport United midfielder could miss this game as he continues to recover from an injury.
The 22-year-old watched the last two games which Zwolle failed to win from the stands, and his absence was felt in the middle of the park where he normally plays.
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