Mokotjo and Serero will face each other when eighth-placed PEC Zwolle welcome log leaders Ajax Amsterdam on Sunday afternoon
Kamohelo Mokotjo will also be in action when PEC Zwolle host leaders and Thulani Serero's Ajax Amsterdam on Sunday afternoon.
The two South African national team teammates have done well for themselves in the Eredivisie so far this term, and this is in an important encounter for both of them.
Mokotjo will be looking to impress against the champions by cutting Amsterdam's attacks in his defensive role while Serero will be aiming to get his name on the score sheet.
This crucial encounter will also be an opportunity for the Dutch giants to extend their lead to seven points at the top of the Eredivisie log.
Having made his official KV Oostende debut against KSC Lokeren in a Belgian Cup on Wednesday, Andile Jali will be hoping to get some game time in the league when his side welcome KAA Gent on Saturday night.
The hard-tackling midfielder impressed during his debut, and it wouldn't be surprising if he's named in the starting line-up this weekend.
Ayanda Patosi's Lokeren will also be at home against Royal Charleroi SC on Saturday as the Belgian Jupiler League edges closer to its conclusion.
Lokeren will be buoyed by the fact that they've just reached the final of the Belgian Cup, and will be looking to build from it going forward.
Darren Keet is unlikely to feature for KV Kortrijk against Anderlecht on Saturday. Keet was relegated to the bench during Kortrijk's last weekend 1-1 draw at Waasland-Beveren.
New captain Anele Ngcongca will lead Racing Genk against Club Brugge on Sunday afternoon.
Genk collected all three points in their previous encounter, and they are still hoping to finish into the top four teams to be able to return to Europa League football next season.
Kagisho Dikgacoi has returned to full fitness, and after playing the entire 90 minutes against Arsenal last weekend, he is expected to play when Crystal Palace host West Brom Albion on Saturday.
Steven Pienaar should also feature when Everton travel to White Hart Lane to face Tottenham Hotspur.
'Schillo' was instrumental in Everton's 2-1 victory over Aston Villa last week, and he's definitely enjoying his football under manager Roberto Martinez.
In the Championship, Tokelo Rantie's AFC Bournemouth visit Bolton Wanderers on Saturday, and the former Pirates marksman is expected to travel with the team despite struggling last weekend.
Rantie has consistently made Eddie Howe's squad since moving switching from Sweden to England, and the Cherries manager previously expressed his delight at having the 23-year-old forward at his disposal.
Midfielder Andrew Surman is one player rated highly by the Bournemouth manager, and he certain of a place in the starting line-up this weekend.
Former Bafana Bafana captain Bongani Khumalo is expected to keep his place when Doncaster Rovers visit Brighton & Hove Albion on Saturday.
The 26-year-old center-back has been rock solid for Rovers in the past two games, and will be expected to produce the same level of performance against their opponents.
Dean Furman, who has lately been used as an impact player, should also get some game time. He joined Rovers from Oldham Athletic last year, and remains one of their important players.
In the League One division, Kgosi Ntlhe's Peterborough United will be away to Leyton Orient on Saturday, and the South African youngster will be hoping to make the starting line-up.
Siyanda Xulu will be involved in friendly match when FC Rostov host FK Sloboda Uzice this afternoon (Friday).
The Russian Premier League is still on the winter break and it is set to resume in March, and Xulu's side is keeping fit in preparation of the second half of the season.
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