The Dutchman sat out the Red Devils' last two matches but team-mate Wayne Rooney has made up for it with some sensational form
That was their biggest away win in the competition for 50 years, and it also put them through to the next stage. And David Moyes will be pleased to have achieved it without captain Nemanja Vidic and his star striker, who were both injured.
Both had also missed the preceding 2-2 draw against Cardiff City, where the Red Devils dropped two points after conceding a late equaliser.
That had seemed to suggest that United missed Vidic and Van Persie, but those doubts were emphatically repelled by the demolition of the second-placed team in the Bundesliga side in Germany.
When asked whether Van Persie was missed, a majority of Goal Singapore readers indicated that this was not the case.
55.7% feel that the Dutch star's absence has been made up for by Wayne Rooney's sensational form, with the Englishman grabbing an incredible four assists against Leverkusen. The England striker also scored the first and created the second against Cardiff and his scintillating displays has led to Rio Ferdinand hailing him at the club's "best player this season". With eight goals and 12 assists in 15 games, that certainly seems to be the case.
The other 44.3% begged to differm saying that United need Van Persie back from injury soon. But with Shinji Kagawa linking up well with Rooney while playing behind him in the "hole", Moyes will have a selection dilemma when they entertain Tottenham this weekend.