The former Bafana Bafana captain could miss a month of Premier League action as his injury has yet to heal. Goal South Africa also looks ahead to the weekend action for SA stars
Everton and former Bafana Bafana midfielder Steven Pienaar sustained an injury in training, and will miss up to four games for the Toffees. This includes away trips to West Ham United and Manchester City, which is a major blow for new Everton manager Roberto Martinez.
Everton will play West Ham on Saturday without their creative spark in midfield, while Pienaar is also set to miss games against Fulham and Newcastle United.
Similarly Crystal Palace will also be without their South African midfielder Kagisho Dikgacoi, as he serves a one match ban for his controversial red card against Manchester United. Palace host Swansea City on Sunday and will need to strengthen the midfield without their enforcer Dikgacoi.
In the Championship, Bongani Khumalo will start for Doncaster Rovers when they host Nottingham Forest on Saturday, while Dean Furman will hope to qualify for the starting lineup after spending a few weeks on the bench.
Tokelo Rantie made his first appearance for Bournemouth on Tuesday, coming off the bench for 35 minutes. The new signing will hope for a starting berth when his side travels to Middlesborough on Saturday.
League One sees Kgosi Ntlhe's Peterborough United host Milton Keynes Dons, with Darren Ferguson's side lying in second on the league standings. Ntlhe was not named in the squad for the last league match and will hope to regain the faith of Ferguson for this weekend's encounter.
Thulani Serero will have no rest after Barcelona thumped Ajax Amsterdam on Wednesday night, with Ajax set to meet great rivals PSV Eindhoven in a league clash on Sunday. Ajax currently rest one point behind PSV on the league standings and Serero will want to help his side leapfrog their rivals.
Kamohelo Mokotjo will also be in action this weekend for PEC Zwolle, as the current Eredvisie leaders look to get their season back on track after a disappointing loss to Ajax Amsterdam in their last game. Mokotjo will travel with his side to Vitesse for their match on Sunday.
Sive Phekezela will hope to have more of an influence at Gefle after residing on the bench for most of this season, when his side travel to Kalmar for a Allsvenskan clash [Swedish league].
Ayanda Nkili should be involved in the Superettan [Swedish Second Division] on Friday night as his side meet Angelholm away from home and seek to get within one point of Superettan leaders Falkenberg.
Ricardo Nunes will play for Zilina on Saturday, when they host Kosice in the Slovakian league. Zilina are currently in eighth position on the league standings and will want to strive for victory at home in order to climb towards the upper echelons.
After Genk sealed a surprise 1-0 win in the Uefa Europa League against Dynamo Kyiv on Thursday night, Anele Ngcongca will not have much time to recover as his side travel to Waasland-Beveren on Sunday night.
Darren Keet will be in goal when Kortrijk travel to Lierse, while Ayanda Patosi will strive for a starting berth when Lokeren play Standard Liege on Sunday.
Siyanda Xulu faces another tough test against Zenit St. Petersburg on Sunday, with the central defender's club Rostov looking to recover from a loss to league leaders CSKA Moskow in their last game.
Daylon Claasen should be selected for Lech Poznan's home match against Pogon Szczecin on Friday night, as the midfielder's new side seeks to move into the top half of the Polish league standings.
After losing 1-0 to AZ Alkmaar on Thursday night in the Uefa Europa League, life does not get any easier for Dino Ndlovu's Maccabi Haifa as they prepare to play Maccabi Tel Aviv on Monday night.