Kagisho Dikgacoi will look forward to facing Manchester United on Saturday, while Thulani Serero and Kamohelo Mokotjo are set to face each other in a crunch Eredivisie clash
The Eagles defeated Sunderland in their last league match and will strive for a passionate display against the Premier League heavyweights, while Everton seek their first win of the season after three straight draws.
Staying in England, Dean Furman and Bongani Khumalo will be in action for Doncaster Rovers in the Championship, with the side set to meet Huddersfield Town away from home on Saturday.
Tokelo Rantie will hope to earn his first start for new side Bournemouth, when the Championship club play Blackpool at home.
Kagiso Nthle will want to fight his way back into Peterborough United's starting lineup after sitting on the bench for their last game. Peterborough travel to Bristol City on Saturday for League One encounter.
To the continent, where we start in Belgium. Anele Ngcongca's Genk will play Zulte Waregem in the Belgian PRO League, with the Bafana Bafana full back's team looking to move into the top six on the league standings.
Darren Keet, returning from Bafana duty against Zimbabwe on Tuesday night, will hope to start against Gent on Saturday night as his side Kortrijk resume their league campaign. Ayanda Patosi will hope to start for Lokeren as he makes his return from injury.
In the Netherlands Thulani Serero will want to put his national team debacle behind him when Ajax Amsterdam host Kamohelo Mokotjo's PEC Zwolle in a potential humdinger on Satruday.
Zwolle currently top the standings in the Eredivisie, with Ajax seeking to improve after a surprising poor start to their campaign. Whether both South Africans face each other remains to be seen, but the result of the match could prove vital.
Moving to Russia, where Siyanda Xulu's FK Rostov are in action against CSKA Moskow on Saturday, during a vital league encounter between the two sides. Xulu will have to contend with the likes of in-form strikers Ahmed Musa and Seydou Doumbia during the clash.
After scoring in his opening game for Lech Poznan in Poland, Daylon Claasen will want to star again for his new side as they play Slask Wroclaw in the Polish league this weekend. Other players in action include Brondy FF's Lebogang Phiri in Denmark, while Ayanda Nkili and Bradley Ralani should continue their Superttan campaigns for Swedish outfits Orebro and Landskrona.