Anele Ngcongca and Dino Ndlovu both turned out for their club sides in Uefa Europa qualification on Thursday night
Ndlovu was involved for 12 minutes of the match, making his return from an injury which kept him out of action for the entire pre-season.
Maccabi Haifa will begin their league campaign this weekend and Ndlovu will hope he can re-ignite the form which saw him become the most potent South African striker abroad last season.
Ngcongca returned for Genk after missing a league match last weekend and is set to play for his side when they host Cercle Brugge in the Belgian league on Sunday.
In Sweden, Bradley Ralani and Andile Nkili both suffered defeats in the Svenska Cupen on Thursday night. Nkili's side Orebro were dumped out of the competition by Hudiksvalls, while Ralani's Landskrona suffered the same fate against Rynninge.
Looking ahead to the action this weekend, Kagisho Dikgacoi and Crystal Palace face another tough test of their English Premier League credentials as they travel to Stoke City on Saturday. Dikgacoi played his team's first match against Tottenham Hotspur and was a brick wall in the midfield.
Steven Pienaar will look to help inspire Everton to victory as they face West Bromwich Albion in their second league match of the season, after drawing 2-2 with Norwich City in their opening encounter.
In the Championship, Bongani Khumalo's fine form in the Doncaster Rovers jersey should continue as his team faces Charlton Athletic. Dean Furman will return for Rovers after being rested during their previous match.
League One outfit Peterborough and Kagisho Nthle will look to replace Leyton Orient at the summit of the league standings when they travel to Tranmere Rovers on Saturday.
On the continent, Tokelo Rantie will play for Malmo FF when they host IFK Goteberg in the Allsvenskan. Malmo and Helsingborg are currently gunning for top position in the league standings, with the two teams locked on the same points at the summit of the table.
In the Netherlands, Kamohelo Mokotjo's PEC Zwolle are set to host Cambuur in the Eredivisie, while Thulani Serrero's Ajax Amsterdam travels to Heerenveen on Friday night.