The Benfica great lifted the European Cup with the Aguias in 1962, was named European Footballer of the Year in 1965 and scored nine goals at World Cup 1966.
He is rightly regarded as one of the greatest players to ever play the game, with tributes flooding in from some of football's finest via Twitter.
Goal rounds up the latest tweets from across the globe, with two more of Portugal's finest footballers paying their respects along with a host of respected figures and institutions.
TRIBUTES IN TWEETS
Always eternal #Eusebio, rest in peace
RIP Eusebio (1942-2014). One of the greats
The king!! Grande perda para todos nos! O mais grande!!
Sad to hear that Eusébio has passed away. 733 goals in 745 appearances will always mark him down as a true legend of the game. R.I.P.
Respect to a man who meant so much to the game I cherish. Eusebio, one of the all time greatest, may he Rest In Peace.
We're saddened to hear Benfica legend Eusebio has passed away. He was a fantastic player and a friend of the club.