The 44-year-old is expected to undergo surgery on Thursday following the return of a cancerous tumour in his throat.
And Goal.com International has compiled tweets from from around the world, wishing the Camp Nou coach well as he faces a battle back to full health.
"Thanks to everyone for your support. Everything is gonna be alright. Greetings"
Tito's son Adria Vilanova.
"Very sorry to hear the news about Tito Vila. Thoughts are with him and his family. #AnimsTito"
Retired Spanish footballer Gaizka Mendieta @GaizkaMendieta6
"Very sorry to hear Tito Vilanova, the Barca coach, is undergoing surgery after a cancer relapse. Thoughts are with him."
BBC Match of the Day presenter Gary Lineker @GaryLineker
"All my support and best wishes to Tito and all of the people in the world fighting every day against cancer. Be strong #AnimoTito"
David Silva 21@LVA of Manchester City showing his support for the Barcelona boss.
"We hope for your recovery my friend !! Good luck Tito !! #Animstito"
Manchester City's Javi Garcia @javigarcia06
"All strength to Tito Vilanova! We are all with you!!#AnimoTito"
Manchester United's goalkeeper David De Gea @D_DeGea
"We support you, #AnimoTito! We wish you the strength to overcome this moment."
Sergio Aguero @aguerosergiokun
"All my strength and support to Tito Vilanova! We are all with you in overcoming this new step.#AnimsTito"
World number four and 11-time major tournament winner Rafael Nadal @RafaelNadal
"From here all my support to Tito Vilanova, people and your health are greater than anything.animo"
Former Real Madrid player Guti @GUTY14HAZ