The two Premier League giants meet in the weekend's biggest clash and the Blues have been favoured to emerge victorious
Currently nine points behind the Blues in the table, the seventh-placed Red Devils will hope to narrow the gap, especially as both leaders Arsenal and second-placed Manchester City won their games last night.
David Moyes's men drew 0-0 with Jose Mourinho's charges earlier in the season but the test at Stamford Bridge will be a tougher one, with United having failed to beat Chelsea in any of their last five meetings.
The hosts, who will be looking for a 100th Premier League win under Mourinho's charge, will be the clear favorites and the majority of Goal Singapore readers appear to feel that way as well.
More than half picked Chelsea to emerge victorious, with 56.1% voting in favour of a home win. Only 25.5% think United can win, while the remaining feel that it will end in a draw.
With star strikers Robin van Persie and Wayne Rooney ruled out, Moyes's task will not be made any easier. Chelsea could give new signing Nemanja Matic a debut, while Frank Lampard is in line for a recall.
The game will kick off at midnight tonight, Singapore time.