The former France international is full of respect for the Portuguese but fully expects to be on the receiving end of some snide comments in the coming days
The French champions are seeking to reach the last four of the competition but face a daunting meeting with the Premier League leaders in the quarter-finals.
And, despite his respect for Mourinho's achievements throughout his career, Blanc says that big talk is part of the package with the Portuguese.
"Mourinho will talk and comment, that's how he functions," he told a press conference.
"He's very clever and very professional. I have a lot of respect for him. He's a great coach who has won nearly everything. I know him very well because he was on Bobby Robson's coaching staff when I played for Barcelona.
"I know he will prepare well for this match with us because he is a very professional coach.
"We mustn't underestimate Chelsea. But like I have already said, they are no stronger or weaker than when the draw came out. They are a great side and they proved it last week with that big win over Arsenal."
Meanwhile, Blanc has confirmed that Thiago Silva should be fit to face Chelsea, despite fracturing his cheekbone earlier this month.
"Thiago Silva is fine, it's up to him to decide if he wants to play with or without a mask. If he decides to play with a mask, we have to ask Uefa for permission to wear it against Chelsea."