Roberto Martinez's find themselves five points from safety after Aston Villa's thumping 6-1 win over Sunderland on Monday, but the Baggies boss has dismissed suggestions his side will go easy on the Latics as they have nothing to play for.
Clarke admitted on Wednesday that he hopes Villa remain in the Premier League as the Midlands rivalry would benefit his squad, and he reiterated this point to the press on Thursday.
|PREMIER LEAGUE PREVIEW
|3/1||West Brom are 3/1 with William Hill to beat Wigan with Romelu Lukaku scoring
"Maybe Southampton thought last week that it was a mid-table clash with nothing on it. We certainly went down there and showed them it mattered to us and that we wanted the points.
"It's no different this time. We have our own ambitions and our own targets. We like to finish the season well and play well in front of our own fans. The game against us, I can assure you, will be difficult, because we've been good at home."
It has been suggested that Wigan's FA Cup final berth will distract the squad from their fight against relegation, but Clarke feels the Latics' experience at the bottom could give them the edge as they battle for survival.
Clarke added: "The cup final will take care of itself. They've got league matches they have to look at. Wigan are a team who are, and maybe this is not the right word, quite comfortable down there fighting.
"Over the years they've always been in the lower reaches and they know what they have to do to get out of it. They've got a manager in Roberto Martinez who doesn't panic and he knows there are points still to be had."