The 71-year-old has revealed that he will ring the changes between Sunday's clash with Everton at Old Trafford and Wednesday's Champions League meeting with Real Madrid
The Red Devils face Champions League-chasing Everton at Old Trafford on Sunday before a Champions League last-16 clash with Real Madrid.
And the Scot says he must place his full trust in his players in order to ensure he has fresh legs in both games.
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“I trust the squad of players I have. They are all internationals, they are all good players and there is no reason why I can’t play them.
“They’re all contributing in their own way and that gives us a better chance of dealing with the various competitions we’re in.”
The United manager also lamented the fact that preparations have been disrupted by midweek international friendlies, adding: “There is not a domestic manager who can agree to friendly internationals at this time of year."
However, he did concede that the confidence boost provided by England's 2-1 win over Brazil could help two members of his squad.
“I was happy for Wayne Rooney and Chris Smalling to play full games at Wembley because they have not had a lot of football anyway," he concluded.