The Gunners will be without their captain who is still struggling with an ankle injury whilst England left-back Gibbs is still recovering from this thigh strain picked up in the 2-2 draw with Liverpool last month.
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Laurent Koscielny limped out of France's clash with Germany in midweek and will face a late fitness test on the calf injury that he sustained in the game although Wenger claimed that early scans were "reassuring".
The lack of options at the back could be a worry for the Frenchman, who took time to praise the attacking talents of the Black Cats ahead of Saturday's game.
"They have real offensive potential, with Johnson, Fletcher, Sessegnon and now Danny Graham," the Gunners boss told reporters during his pre-match press conference.
The 63-year-old revealed better news on the injury front as both Aaron Ramsey and Francis Coquelin are expected to be fit for the trip to the Stadium of Light.