The 22-year-old's Bundesliga side played their last match of the year on Friday and will not play again until January 19, giving them a break of over four weeks.
With the likes of league leaders Manchester United facing six games in that period of time, Holtby thinks it would be good for players in England to be able to spend the Christmas period with their families instead.
"I know how important football is to English fans over the Christmas break, but it must take its toll on the players," he told reporters.
|8/1||Manchester City are 8/1 with William Hill to secure two or fewer points over the festive period|
"The break in the Bundesliga gives everyone the chance to have a rest.
"We also get the chance to go back and spend time with our families over Christmas, which is important.
"For the rest of us it doesn't make too much sense because when players are tired and playing so regularly you do pick up little niggles and injuries."
Arsenal star Santi Cazorla also recently backed a winter break for clubs in England, stating it would be a psychological boost for players to be able to disconnect from football over the holiday season.