In total Sir Alex Ferguson has made five changes from the weekend as Chris Smalling comes in for Rio Ferdinand in defence, and Anderson replaces the suspended Paul Scholes.
Alongside Anderson are Tom Cleverley and Michael Carrick, while in attack Javier Hernandez comes back into the team as Ashley Young, Darren Fletcher and Danny Welbeck all take places on the bench.
West Ham suffered a London derby defeat at the hands of Tottenham last time out and Sam Allardyce has decided to make a handful of changes in response.
Guy Demel and James Collins return to the team in defence, replacing George McCartney and Gary O’Neil, while a formation change sees Andy Carroll operating along in attack.
Modibo Maiga partnered the England international at the weekend, but the Malian takes a place on the bench as Matt Jarvis starts on the left. Matt Taylor also plays from the off, taking the place of the injured Mark Noble.
Manchester United: Lindegaard; Rafael, Smalling, Evans, Evra; Anderson, Carrick, Cleverley; Hernandez, Rooney, Van Persie.
Subs: De Gea, Jones, Ferdinand, Young, Welbeck, Fletcher, Buttner.
West Ham: Jaaskelainen; Demel, Reid, Collins, Tomkins, O'Brien; Jarvis, Diame, Nolan, Taylor; Carroll.
Subs: Spiegel, Spence, Maiga, Cole, Lletget, O'Neil, Moncur.