Andre Villas-Boas' side travel to St Mary's to face Nigel Adkins' men and you can be there to watch it in personPremier League, to offer one lucky reader the opportunity to win a pair of tickets to Southampton v Tottenham on Sunday October 28.
To be in with a chance of winning the tickets, simply send your answer to the following question along with your name, address and telephone number to email@example.com.
Tottenham duo Mousa Dembele and Clint Dempsey were signed from which club this summer?
A) Aston Villa
D) West Brom
The competition will close at 1700 BST on Wednesday, October 24 and winners will be announced by Friday, October 26 but don't worry if you're not successful - you can always win a pair of tickets by visiting your nearest Barclays ATM and requesting a receipt or by going online to www.barclaysticketoffice.com – you don't even have to be a Barclays customer.
Match tickets are up for grabs EVERY 90 minutes, every day, throughout the 2012-13 season.
Further information and terms and conditions are available from www.barclaysticketoffice.com.