The Red Devils have won just two of the last eleven Premier League meetings between the sides at Ewood Park and with the home side battling against relegation this season, Monday's encounter between the two could prove to be another stern test.
When asked about the statistic at a press conference the Scot said: "I couldn't answer why.
"When Blackburn score first they make it difficult for you, so maybe the answer is to make sure we keep our noses in front."
After suffering an early elimination from European competition the champions should head into the game with a lot of energy but it is an advantage Ferguson wishes he didn't have.
"We have been used to playing midweek games for so long that you do miss it," he admitted.
"The players miss it too. Yes, we do get freshness but you can't have it all ways. We would rather be in the Champions League."
Speaking about the opposition Sir Alex praised fellow countryman Steve Kean and believes Rovers fans will now be regretting how they responded to him earlier in the season.
He continued: "I am sure a lot of them are saying to themselves 'I wish I hadn't done that'.
"Things can change. You have to dig in and not let it get to you, now no one is talking about fans having protest marches.
"He has held his dignity very well and deserves 100 per cent praise from everyone, including his own supporters.
"He has shown his mettle in times when it was difficult for him."