The 24-year-old midfielder, representing France at this summer's World Cup, has attracted keen interest from Arsenal and Napoli and has decided that he will quit the Saints
France midfielder Morgan Schneiderlin is set to follow Mauricio Pochettino, Luke Shaw and Adam Lallana out of Southampton this summer, Goal understands.
Schneiderlin has told the Saints he wants to leave the club and has been attracting plenty of interest, particularly from Arsenal and Napoli.
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However, Serie A club Napoli have already held talks with the 24-year-old's representatives and settled on a deal to raise his annual salary by £319,000, from £478,585 to nearly £800,000 plus bonuses.
Rafa Benitez's side also believe they are battling Tottenham for Schneiderlin's signature, and they would ironcially strengthen Spurs' need for a central midfielder if they are successful in their attempts to sign Sando.
Schneiderlin could join up with former Saints boss Mauricio Pochettino should he decide to move to Spurs.
The Argentine boss moved to White Hart Lane at the end of May, sparking a firesale at the south-coast club.
Shaw completed a £30 million switch to Manchester United on Friday, while Lallana joined Liverpool for £25m.
Striker Jay Rodriguez, who had been tipped to make England's World Cup squad until damaging his medial knee ligament towards the end of the Premier League season, has also been linked with a move to Tottenham, while centre-back Dejan Lovren is said to be on Arsenal's radar.