The long-serving Nerazzurri pair will bid farewell to San Siro this summer as Walter Mazzarri's side continue their overhaul of the playing squad, with fifth place guaranteedInter sporting director Piero Ausilio has announced that Esteban Cambiasso and Diego Milito are to leave the club at the end of the season.
The Argentine pair both have expiring contracts with the Serie A giants and neither will be offered an extension, though Ausilio is hopeful that the midfielder, at least, will be back at the club one day in some capacity.
"I speak to Cambiasso every day in an informal manner as he is a friend," he told reporters.
"This time there was a difficult moment between him and I, as we talked about the future. Due to reasons of strategy, renewal and an Inter for young players, he will not be confirmed in the squad for next season.
"We will not propose a new contract. He understood this and sooner or later will return to us."
Ausilio then spoke of Milito's professionalism and his hopes that the striker will bow out with a victory and a goal on Sunday evening when Inter face Chievo in their final Serie A game of the season.
"We said to each other it was preferable to change, he knows that," Ausilio added.
"Milito does not represent a problem for us as he is a professional who loves our club colours.
"I would like to win [on Sunday] with him as a protagonist. It would be great closure."