The Uruguay international has not made a single Premier League start this season and is considering a return to Italy to kick-start his career ahead of the World Cup
Ramirez has struggled to hold down a regular first-team place at St Mary's since his £12 million signing from Bologna in the summer of 2012, and has not made a single Premier League start this season.
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"Inter have been in touch with me two or three times already," Pablo Betancourt told calciomercato.com.
"There are lots of South Americans at the Nerazzurri and Italian football was what launched him in the first place, so it would be perfect.
"I've got to meet with the president of the English club and we've got to see whether Ramirez will remain in the Premier League or return to Italy, it doesn’t matter where.
"All that matters is he plays in the run-up to the World Cup.
"The only problem will be talking to the president of Southampton, Nicola Cortese, who has always handled my client with kid gloves."