The Mexico international joined Los Blancos on a season-long from the Red Devils just before the close of the summer transfer window.
Madrid have the option to make the deal permanent next summer and Ferguson, who brought the striker to Old Trafford from Guadalajara in 2010, is in no doubt that 'Chicharito' will end up staying at the Santiago Bernabeu.
"He will do very well in Madrid," the Scot stated at a Uefa coaching conference. "He will score many goals, for sure.
"He's very focused mentally and his wish was always to play in Madrid. He will come good there."
Hernandez, who represented Mexico at this summer's World Cup, scored 59 times in 154 appearances in all competitions for United.