Jose Mourinho's side came from a goal down to beat Burnley at Turf Moor on Monday night, a result that capped a weekend of wins for most of the Premier League favourites6/4 (2.50) to claim this season's Premier League title.
Cesc Fabregas' man of the match performance has seen the bookmaker cut the Spaniard's odds of winning the PFA Player of the Year award from 20/1 (21.0) to 12/1 (13.0). Robin van Persie still leads the way at 8/1 (9.0) with Eden Hazard available at 9/1 (10.0).
Meanwhile, Diego Costa's debut goal sees him as 4/1 (5.0) favourite to finish as the division's top scorer ahead of Daniel Strurridge and Sergio Aguero (5/1) who both opened their accounts on the opening weekend.
Manchester United were the only club listed in the top five pre-season contenders not to grab three points on the opening weekend as Louis van Gaal's side went down 2-1 to Swansea in the opening game of the campaign.
United, who had been very well backed in the Premier League winner market over the last few months have drifted from 5/1 (6.0) to 8/1 (9.0) after their defeat to the Swans. That's still a price that still appears to factor in some significant investment in a squad which is in desperate need of reinforcements before the end of the summer transfer window.
William Hill have Chelsea as firm favourites to finish top of the table with Manchester City next in the betting at 9/4 (3.25) after Manuel Pellegrini's side picked up a 2-0 win over Newcastle at St James' Park on Sunday.
Arsenal, like Chelsea, had to come from a goal down as a Brede Hangeland header gave managerless Crystal Palace a surprise lead at the Emirates but an injury time Aaron Ramsey goal won it for the Gunners after Laurent Koscielny levelled the scores.
Liverpool are still behind Manchester United in the betting at 10/1 (11.0) following their 2-1 win over a new look Southampton side who proved they will still be a match for most sides in the divison under Ronald Koeman.
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