Having successfully secured a goalless draw in the away leg, Jose Mourinho's men are 13/10 (2.30) favourites with bet365 to complete the job by coming out on top in 90 minutes.
However, the visitors come into this clash on the back of a nine-match winning streak in the league and are available at 5/2 (3.50) to record a victory that would see them to their first European Cup final since 1974.
Los Colchoneros picked up a 1-1 draw at Camp Nou on the way to knocking out Barcelona in the quarter-finals and you can get odds of 23/10 (3.30) on them holding on for another stalemate in this one.
Although Mourinho made no secret of his annoyance at having to face title rivals Liverpool in the middle of such crucial European commitments, the lack of preparation time was arguably negated by the manager's almost identical gameplan for each fixture.
Having masterminded a defensive performance in Madrid on Tuesday, the Portuguese boss was able to take almost the same tactical blueprint to Anfield on Sunday, albeit with a few changes to personnel.
While the hosts may have to show slightly more ambition in front of their own fans, they are unlikely to take too many risks against a similarly ruthless counterattacking outfit, meaning that a cagey affair should be in the offing.
A return of just seven goals scored in their last seven games in this competition suggests that Chelsea should struggle to break down a side who have only conceded five in 11 Champions League ties this season, while their own record of four consecutive European home clean sheets implies that defences should be very much on top.
Considering that this pair have conceded just 12 goals in 22 games combined in Europe this season, odds of 6/4 (2.50) seem safe on no more than one being scored when they come face-to-face in a tight match.
|Under 1.5 goals for a 1.5pt stake at 6/4 (2.50) with bet365
New bet365 customers can claim a first deposit bonus of up to £200
Al Hain-Cole is an experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.
Love Champions League football? Then you’ll love the great DVDs on offer at Goal’s Official DVD Store – click here to take a look!