Scoring however, has not been a problem for Los Blancos when Ronaldo has been missing this season and there will be plenty of players capable of finding the back of the net.
For Barca of course Messi remains the most potent threat and his two goals (both from the penalty spot) in last month's La Liga Clasico saw him become the highest scoring player in the history of the world's greatest fixture.
He is offered at 3/1 (4.00) to open the scoring and at 8/11 (1.72) to score at any time.
Punters can never discount one of the most naturally gifted men ever to have played the game, though Messi and indeed Barca as a whole have been a little off colour recently.
He has managed just one goal from open play in his last five matches, which by his admitedly stratospheric standards, is below par.
While he is always likely to score given his talent not to mention his dead ball capabilities, the price is not appealing and there appears to be a much option elsewhere in the markets.
Instead, a much stronger case could be made for backing Gareth Bale to find the back of the net at 15/8 (2.87).
Injuries look like depriving Barcelona of a number of key defenders and Bale's blistering pace is likely to cause the Catalan club some serious problems.
The Welshman is enjoying his best scoring form in a Real Madrid shirt having netted four goals in his last three La Liga games, and Bale seems to be 100 per cent physically fit so he should relish such a high profile clash against a somewhat makeshift Barca backline.
He can be backed at a healthy looking 7/1 (8.00) to open the scoring, but instead investing in him to get on the scoresheet at any time looks a great option and at 15/8 (2.88) it offers plenty of potential returns too.
|Gareth Bale to score at any time at 15/8 (2.87) for a 2.0pt stake with bet365