With seven wins from seven, Rudi Garcia has enjoyed the perfect start to life in the Eternal City and his side are available at 6/5 (2.20) with bet365 to extend their lead at the top by maintaining that 100 per cent record.
Rafa Benitez's return to Italian football has proved similarly seamless, having garnered 19 points from 21 games, but his side are outsiders at 11/5 (3.20) to clinch top spot with victory over their southern rivals.
Just five of the last 22 encounters between these opponents have resulted in draws but you can get odds of 12/5 (3.40) on them sharing the spoils this time out.
While neutrals tuning will be hoping for an entertaining clash between the league's highest scorers, the fact that this game is already being touted by some as an early title decider underlines the pressure that both teams will be under in the capital.
At this stage, avoiding defeat may be even more important than coming out on top for both teams and neither are likely to take too many chances in throwing people forward.
Having conceded just four goals between them so far, these opponents are equally adept at the back as they are in attack, and it is this defensive prowess that is likely to come to the fore in a tense encounter.
Benitez is sure to line the Partenopei up in an organised fashion in the hope of collecting a fifth clean sheet in six while attacking quickly on the break and, with both teams crowding the midfield, it would be no surprise if the result boiled down to something of a tactical game of chess.
When this occurs goals are rarely free-flowing and odds of 43/40 (2.08) are therefore not to be missed on under 2.5 goals going in.
|Under 2.5 goals for a 1pt stake at 43/40 (2.08) with bet365
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Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.