The Chelsea man makes his 95th international appearance, while Theo Walcott misses out through injury and Ashley Cole is a substitute being just one booking away from suspension
Regular skipper Gerrard has been placed on the substitutes bench while Ashley Young, Leighton Baines and Alex Oxlade-Chamberlain - scored his one and only international goal in the reverse fixture in October - have all been handed starts.
Lampard makes his 95th England appearance, while Ashley Cole also misses out on a starting berth being just one booking away from suspension.
San Marino starting XI: Aldo Simoncini; Fabio Vitaioli, Palazzi, Alessandro Della Valle, Davide Simoncini; Cervellini, Gasperoni, Cibelli, Fabio Bollini; Selva, Matteo Vitaioli.
Subs: Federico Valentini, Bacciocchi, Bianchi, Buscarini, Coppini, Alex Della Valle, Rinaldi, Carlo Valentini, Vannucci.
England starting XI: Hart; Walker, Lescott, Smalling, Baines; Oxlade-Chamberlain, Lampard (c), Cleverley; Defoe, Rooney, Young
Subs: Parker, Foster, A Cole, Taylor, Caulker, Milner, Gerrard, Carrick, Osman, Welbeck, Sturridge, Forster