City are the overwhelming 2/9 (1.22) favourites for this fifth Round clash with Coral, despite suffering defeat last time out at Southampton in the Premier League.
Having already exited the Capital One Cup and the Champions League this season - and now 12 points behind Premier League leaders Manchester United - the FA Cup seems the most likely chance of silverware for the club.
Therefore, Mancini is likely to play a strong side for the visit of Leeds, who are available at a long shot 11/1 (12.0) for victory.
The Whites shocked Tottenham in the last round of the cup, but that was at Elland Road and the Yorkshire outfit have not progressed well since that rousing win.
Two defeats and a draw followed for Neil Warnock's side, who would be happy to take a stalemate in this game at 5/1 (6.0) and force City back to Leeds for a replay.
Both of Leeds' defeats since the Spurs match have come without them scoring, while seven of City's last 11 games in all competitions have been victories with clean sheets.
A win to nil against Leeds is a probably scenario for the hosts at 4/5 (1.80), given further likelihood by the fact that City haven't conceded a goal in their two FA Cup triumphs - over Watford and Stoke - so far.
Although the Citizens' recent form has been bumpy - two draws and a defeat in the league since their Fourth Round cup win - Mancini will demand a response from his team who won this competition in the 2010-11 season, especially given the pressure on this being the only realistic chance of silverware this season.
With that in mind selecting a winning scoreline to nil for City offers more appealing odds, with 2-0 at 19/5 (4.80) and 3-0 at 10/1 (11.0) standing out.
Bearing in mind City's recent slump and Leeds' decent cup form this term - they also made it to the Capital One Cup quarter-finals - backing a 2-0 home win could be a handy long shot.
|Manchester City to win to nil at 4/5 (1.80) with Coral||Manchester City to win 2-0 at 19/5 (4.80) with Coral|
Coral offer a free bet of up to £50 for all new customers, read more here
Jamie Dickenson is a 22-year-old freelance journalist who specialises in football, sports and betting.
More of his work can be found here - and you can also follow Jamie on
Follow GoalBetting on