After another disappointing result against Swansea on Saturday, Roberto Di Matteo's men will be gunning for European revenge when they welcome Mircea Lucescu's side to Stamford Bridge on Wednesday evening.
The Blues have stuttered in recent weeks, winning just one of their last four matches inside 90 minutes but, nonetheless, they are chalked up as 10/11 (1.91) favourites with Paddy Power to grab victory here.
Shakhtar have not lost a competitive fixture in nearly a year since crashing out of last year's Champions League after suffering defeat at the hands of Porto – a run which stretches 37 matches - while it should also be noted that they have won all 14 of their league matches thus far this term.
Despite coming into this tie in such imperious form, the Ukrainian side are rated as a 3/1 (4.0) chance with Paddy Power to win in London while the same firm go 5/2 (2.50) that the match ends in stalemate.
Lucescu's side have already earned an impressive 1-1 draw in Turin against Juventus in this group and look to be underrated against a Chelsea side that has not hit peak form in recent weeks.
Paddy Power go 4/5 (1.80) about the Ukrainians to either win or draw in the double chance market - a quote which looks to represent sensational value considering how difficult the visitors are to beat.
Shakhtar's Armenian midfielder Henrikh Mkhitaryan has been in magnificent form, scoring 14 goals in 13 appearances so far this term.
He is chalked up at 15/2 (8.50) with Paddy Power to score first while Alex Teixeira, who opened the scoring when these sides met in Donetsk, is available at 10/1 (11.0) with Paddy Power to break the deadlock again.
If Chelsea are to claim a much needed victory, they will most likely require a big performance from Spain striker Fernando Torres.
The former Liverpool forward can be backed at 11/2 (6.50) with Paddy Power to score first.
This has all the makings of a hugely entertaining game and the 4/5 (1.80) on offer from Paddy Power for Shakhtar Donetsk in the double chance market should be snapped up here while the in-form Mkhitaryan is the value pick to score first at 15/2 (8.50) with Paddy Power.
|Shakhtar Donetsk and Draw (Double Chance) at 4/5 (1.80) with Paddy Power
||Henrikh Mkhitarayan to score first at 15/2 (8.50) with Paddy Power|
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Willie Duncan is a freelance sports journalist. Willie, from Edinburgh, has covered Scottish football for over 10 years and he specialises in football betting markets from across Europe. You can also follow Willie on Twitter
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