Sam Allardyce takes his team to Spurs looking for a repeat of their 3-0 Premier League win and inflict further torture on the hosts after Andre Villas-Boas was sacked on Monday
Head coach Villas-Boas left White Hart Lane by mutual consent on Monday in the aftermath of Sunday's humiliating 5-0 home thrashing by Liverpool and technical co-ordinator Tim Sherwood has been placed in temporary charge alongside Les Ferdinand and Chris Ramsey.
That defeat left the London club eight points behind top-flight leaders Arsenal, despite the north Londoners spending heavily in the close-season.
|7/2||Jermain Defoe is 7/2 with Paddy Power to open the scoring against West Ham|
West Ham have already won once this season at White Hart Lane when Winston Reid, Ricardo Vaz Te and Ravel Morrison were on target in a surprise 3-0 Premier League triumph in October.
Spurs midfielder Paulinho will start a three-match ban after his red card against Liverpool, while Michael Dawson will miss out after picking up his fifth booking of the campaign in the same game.
Sandro also looks set to be sidelined after suffering a calf injury at the weekend, but Danny Rose (foot) and Vlad Chiriches (knee) could return.
A lack of goals has been a major problem for a West Ham side that are hovering perilously above the Premier League relegation zone.
Sam Allardyce's depleted side were fortunate to secure a point from a goalless draw against bottom-of-the-table Sunderland on Saturday, and he plans to field an experienced team at Tottenham.
"Now, we're in a position where we have to see what we've got available for Wednesday night but there won't be any young players in there that's for sure. But there will be players who haven't played as much in the first team," he said.
Kevin Nolan serves the second of a three-match ban, and West Ham have a lengthy injury list that includes the likes of Stewart Downing (leg wound), Reid (ankle), Andy Carroll (foot), Mladen Petric (calf), and Vaz Te (shoulder).
Alou Diarra, Joey O'Brien, Matt Taylor and Carlton Cole could all be drafted into Allardyce's starting line-up.