Sunday's visitors were beaten 2-0 in the reverse fixture earlier this season, and will be keen to get their revenge against a team who have lost seven of their last eight games
Terlizzi, Paci, Felipe
Angelo, Vergassola, Della Rocca, Rubin
Ranocchia, Juan Jesus, Chivu
Schelotto, Gargano, Cambiasso, Nagatomo
Siena have few injury worries to contend with, as striker Nicola Pozzi (muscle strain) is the only player out of action for this weekend's clash at the Artemio Franchi.
Bianconeri centre-back Neto looks set to move to Zenit St Petersburg, so new signing Christian Terlizzi is likely to be preferred in defence. Head coach Giuseppe Iachini will be without midfielder Francesco Valiani due to suspension.
Inter boss Andrea Stramaccioni has a far lengthier injury list, however, and is without Luca Castellazzi (shoulder), Walter Samuel (Achilles), Dejan Stankovic and Gaby Mundingayi (Achilles).
New signing Ezequiel Schelotto should be fit enough to slot straight into first-team action at right midfield. Antonio Cassano will be paired with Rodrigo Palacio up front for the Nerazzurri, with top goalscorer this season Diego Milito (knee) still not fully fit to start.
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Inter have only won one of their last seven matches in all competitions. The last time Stramaccioni's men won away from home in the league was November 3, at Juventus Stadium.
- Antonio Cassano (pictured, right) has seven assists in Serie A this campaign, leaving him fourth overall behind Marek Hamsik, Francesco Totti and Borja Valero.
- The Nerazzurri are currently top of the fair play table, with 45 yellows and two red cards in their 22 games to date. They topped last year's table, too.
Siena won the last clash 2-0 against the Milan-based side at San Siro - Simone Vergassolo and Valiani were the goalscorers in that unexpected triumph.
Iachini's team have won just the one game in their last five matches, which came against Sampdoria; their other eight Serie A games ended in defeat.
Inter sit fourth in the division on 40 points, while the Bianconeri are rooted to the bottom of the league with just 14 points.