The Londoners are one of only four current top-flight teams against whom the Uruguayan has not found the net, but the Hammers cannot yet counter him with former Red Andy Carroll
The Uruguayan has not scored against the London club in two Premier League appearances, making Sam Allardyce's men one of only four current top-flight clubs to have shut out the red-hot striker.
Southampton, Cardiff City and Hull City are the others, although Suarez has only faced the newly-promoted pair once each.
|15/8||Luis Suarez is 15/8 with Bet365 to score two or more goals against West Ham|
"The responsibility is with the squad," Suarez told reporters. "I know I am the striker and I'll try for the team but I think that we have so many players who can help the team going forward. We'll miss Daniel but we'll try to do well without him."
Jose Enrique (knee) remains unavailable for Liverpool, who will not have to face their all-time record signing, Andy Carroll, despite his return to West Ham training after a foot injury.
The striker has not played all season and Allardyce has stressed that he does not expect the 26-year-old to make an appearance before the turn of the year.
West Ham will also be without the suspended Ravel Morrison and the injured Winston Reid (ankle), while Mladen Petric (calf) is a doubt.
The Londoners have not won at Anfield in 50 years and failed to score on each of their last five trips - although two of those games ended 0-0.