Nigel Pearson's side are four points clear in the table and are vying for promotion to the Premier League, while Jack Butland could be in line to start in goal for the hosts
Nigel Pearson's men sit four points clear at the top of the Championship, and they will be hoping that their third-round trip to the Britannia Stadium on Saturday will offer a taste of what they could be facing on a regular basis next season, should they secure promotion.
Leicester are on a five-match unbeaten run in the league, while Stoke have picked up just one win in the same period - most recently being pegged back in stoppage time by a Leighton Baines penalty in a 1-1 draw with Everton on New Year's Day.
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Leicester do not have the best of records in the FA Cup in recent seasons, having failed to make it beyond the fourth round in seven of the last eight campaigns.
And, with fellow Championship high-flyers Derby County up next in the league on January 10, Pearson may be keeping one eye on that important promotion clash.
One point of concern for Stoke ahead of the game will be their goalkeeping injury crisis.
Asmir Begovic has been sidelined since breaking his finger on Christmas Day, prompting boss Mark Hughes to recall Jack Butland from his loan spell at Barnsley.
The youngster got a taste of Premier League action sooner than he might have expected when Thomas Sorensen was withdrawn with a reported Achilles problem at half time against Everton.
The Dane could be a doubt for the visit of Leicester, along with Andy Wilkinson (foot), who missed the game on Wednesday, while Robert Huth has only just returned to training after a knee injury.
Chris Wood (hamstring), Sean St Ledger (groin) and Tom Hopper (shin) all missed Leicester's 3-1 New Year's Day win at Millwall and are doubtful.