The centre-back says he does not know how far the region's team could go but is confident that they could hold their own
The Spain international, 26, has represented the region on six occasions and is set to feature once more when they take on Cape Verde on Monday.
They are affiliated with neither Fifa nor Uefa so cannot compete in World Cups or European Championships, but Pique is eager to see how they would fare.
"This afternoon, world-class players will be on the pitch," he is quoted as saying by Marca.
"Yes, it is true that we could compete at a high level with other teams, but I do not know how far we could get. It's important to see great football with no injuries."
Pique also gave his backing to team-mate Lionel Messi's Ballon d'Or bid, insisting that the Argentine is the best player in the world.
"Whoever wins it deserves it, but Messi is the best in the world. The team has managed without him in recent weeks, but he is the best and gives us a lot."