The Ghana coach was keen not to assume qualification to World Cup 2014 is assured, despite having hammered the Pharoahs 6-1 on Tuesday
Star striker Asamoah Gyan scored twice as the hosts hammered the visitors, with Sulley Muntari and Majeed Waris also getting their names on the scoresheet on Tuesday.
Appiah resisted the urge to insinuate that his side had one foot in the World Cup finals - four years after they reached the last eight of the 2010 tournament - and urged his men to put the 6-1 win at the back of their minds.
"We should not underestimate Egypt and their strength after this result," Appiah told reporters after the game.
"We should prepare well for the return leg and play like we didn't win by six goals here in Kumasi."
The second leg is set to be played on November 19 in Egypt, with the winner over two legs set to be amongst the final qualifiers for the World Cup next summer.