Things briefly got out of hand ahead of Tuesday evening's friendly in Dallas after an incident involving the midfielder and the defenderRoma midfielder Seydou Keita caused uproar ahead of his side's pre-season friendly against Real Madrid by refusing to shake Pepe's hand and throwing a water bottle at the Portugal international.
The two have endured a troubled relationship ever since Keita's time at Barcelona, when the midfielder accused Pepe of racism after a Spanish Supercup match between Madrid and Barca in 2011.
The 34-year-old had clearly not forgotten about the incident and blanked his nemesis when both teams were shaking hands before kick-off.
Keita then threw a water bottle in Pepe's direction, too, leading to a minor brawl on the pitch involving Sergio Ramos among others.
Meanwhile, Pepe kept his calm following the Malian midfielder's actions and a smile appeared on his face after the projectile narrowly missed him.
Things eventually calmed down after a brief conversation between Xabi Alonso and Keita and Roma would go on to beat Madrid 1-0 in the friendly in Dallas.