The midfielder has grown tired of the post-match excuses of los Blancos after his side won the bragging rights in the first Clasico of the season
The Blaugrana emerged victorious from the first Clasico of the season, with goals from Neymar and Alexis Sanchez in either half ensuring Jese Rodriguez's 90th minute strike was in vain.
But Madrid players were quick to criticise referee Alberto Undiano after the game for his decision not to award a penalty following Javier Mascherano's challenge on Cristiano Ronaldo in the second half.
"Madrid crying about the referee? They always look for excuses. They have no reason to complain, not today, not earlier this season," Busquets said after the game.
"The easy excuse is the referee. Same as always. They cannot complain at all this season about the officials. But if they will, they will."
Sanchez's sublime 78th minute chip provided the game's iconic moment and after Andres Iniesta hailed the Chile international's contribution during his cameo, Busquets moved quickly to do the same.
"It was a wonderful goal by Alexis, it was beautifully crafted," praised the 25-year-old midfielder.
Barcelona now have a six-point cushion over Madrid as they continue to set the early Liga pace, but could see their four-point lead over second-placed Atletico Madrid cut to just one when los Rojiblancos face Betis on Sunday.