Los Blancos reached three figures after picking up an incredible 32nd Primera Division win of the campaign, while their Portuguese star also made history with his header
Cristiano Ronaldo opened the scoring after just 19 minutes with a header before Karim Benzema and Mesut Ozil added to Los Blancos' tally, with the Germany international picking up a double.
The victory sees Madrid break Barcelona's 2009-10 record, when they picked up 99 points, and sees Los Blancos become the first side to secure 32 victories in a single season.
Ronaldo can also celebrate reaching a major milestone as he became the first player to score against every team in a single Liga season.
The goal took his tally in the competition to 46 goals, four fewer than Barcelona's Lionel Messi, who scored against 17 of his club's 19 Liga opponents.
Ronaldo's header was also his 60th goal of the season in all competitions.