The 26-year-old striker has already found the net 20 times in La Liga this term, and Falcao is keen to add to his tally in Wednesday's derby against Los Blancos.
"It would be very special if I score in the derby. Goals in derbies are always special, and those who score will make history. I hope that we win, and it will be even better if I score," Falcao stated to El Mundo Deportivo.
"We are only thinking about winning the match, not about what a loss would mean for Real. We are focused on ourselves and at the opportunity to beat them in our own stadium. We have to remain calm.
"Real Madrid have some great individuals who can decide the game, but they've been very strong as a team as well. Above all, it's their individual quality that stands out though."
Wednesday's encounter at the Vicente Calderon kicks off at 22.00CET.
Starting last month and continuing for 10 weeks, Goal.com is publishing exclusive extracts from Luca Caioli's new book, Ronaldo: The Obsession for Perfection. The third extract, published on Friday, looks at Ronaldo's trial and subsequent signing for Sporting Lisbon at the age of 12. Don't miss it!