The young centre-back has been called up for the first time in his career, while the experienced midfielder has once more been snubbed
The Galatasaray playmaker already missed the international friendly versus Portugal after previously being stripped of the captain's armband for Oranje's Asian tour earlier this summer and has once more been omitted from Van Gaal's squad for next month's games.
Other notable absentees are Fulham goalkeeper Maarten Stekelenburg and Everton defender John Heitinga, while Tim Krul, Kevin Strootman, Klaas-Jan Huntelaar and Daryl Janmaat have been left out due to fitness issues.
Manchester City defender Karim Rekik, currently on loan at PSV, has been called up for the first time, while Jeffrey Bruma returns after a lengthy absence.
Augsburg defender Paul Verhaegh has also made the cut again after making his debut in the draw with Portugal earlier this month.
Netherlands currently sit top of Group D with 18 points from six games, holding a seven-point lead over second-placed Hungary.
|Ron Vlaar||Aston Villa|
|Bruno Martins Indi||Feyenoord|
|Stefan de Vrij||Feyenoord|
|Ricardo van Rhijn||Ajax|
|Marco van Ginkel||Chelsea|
|Rafael van der Vaart||Hamburg|
|Jeremain Lens||Dynamo Kiev|
|Robin van Persie||Manchester United|
|Arjen Robben||Bayern Munich|
|Ricky van Wolfswinkel||Norwich|