Victory for England over Ukraine will leave them huge favourites to qualify from Group H for World Cup 2014.
Roy Hodgson's side, who are level with Montenegro on 15 points but ahead on goal difference, ran out 4-0 winners against Moldova on Friday and they remain the only unbeaten side in the group.
But Ukraine, who hammered San Marino 9-0, are only a point behind and they will sense an opportunity to overhaul their visitors in Kiev.
England have problems up front, too, with Wayne Rooney (head), Daniel Sturridge (thigh) and Danny Welbeck (suspended) all consigned to a watching brief.
That leaves Southampton's Rickie Lambert as their main threat and his international career has got off to a flying start, with two goals in as many games.
England will need to break a pattern that has emerged during their qualifying campaign if they are to earn some breathing space at the top of the group. On each of the previous three occasions that they have won, they have followed it up with a draw.
Ukraine are enjoying an excellent run of form, with 15 goals and four clean sheets from their last four matches.
Mykhaylo Fomenko's men were impressive against England at Wembley last September, when it took Frank Lampard's late penalty to deny them all three points following Yevhen Konoplyanka's first-half opener.