The Nigerian defender is nursing a calf injury and will not play in this weekend's game against the Red Devils who are now under the tutelage of Ryan Giggs
The 33-year-old will miss his side's game to challenge the Red Devils in their first match under new interim manager Ryan Giggs.
“Joseph is still having treatment on his calf but we are hopeful of getting him back in on Monday. He still has a problem and he won’t be ready for this weekend,” said Norwich manager Neil Adams.
The Super Eagles captain is expected to return to full fitness for their game against Chelsea on May 4 at Stamford Bridge.
Yobo will be eager to show the national team coaches he is fit enough to be part of the Nigeria squad to the World Cup in June.
He has made eight appearances for the Canaries since his January loan move from Fenerbahce.