The France midfielder, who signed from Manchester United in the summer, takes over from veteran playmaker Andrea Pirlo alongside Claudio Marchisio and Kwadwo Asamoah in midfield.
That triumvirate will be flanked by Mauricio Isla and Emanuele Giaccherini, with Lucio, Giorgio Chiellini and Leonardo Bonucci playing as a back-three.
Up front, Mirko Vucinic starts alongside Fabio Quagliarella, who made a big impact after coming off the bench in the midweek Champions League draw with Chelsea at Stamford Bridge.
For Chievo, captain Sergio Pellissier makes his 299th Serie A appearance for the club, starting up top alongside Marco Rigoni.
A four-man midfield will consist of Kamil Vacek, Luca Rigoni, Perparim Hetemaj and Cyril Thereau, whilst Bostjan Cesar and Dario Dainelli start at centre-back.
Juventus (3-5-2): Buffon; Lucio, Bonucci, Chiellini; Isla, Marchisio, Pogba, Asamoah, Giaccherini; Vucinic, Quagliarella.
Chievo (4-4-2): Sorrentino; Frey, Dainelli, Cesar, Jokic; Vacek, L. Rigoni, Hetemaj, Thereau; M. Rigoni, Pellissier.