The pair have only recently returned to full fitness and will not feature against Jorge Sampaoli's side next week, but Joachim Low has called up four new faces
Both Reus and Draxler recently returned to full match fitness after a spell on the sidelines due to injury and Low has opted not to take any risks with the duo.
Meanwhile, Bayern Munich midfielder Bastian Schweinsteiger returns after missing Germany's previous game due to physical problems.
Furthermore, Matthias Ginter (Freiburg), Shkodran Mustafi (Sampdoria), Pierre-Michel Lasogga (Hamburg) and Andre Hahn (Augsburg) could all make their debut for the Nationalelf after receiving a call-up for the first time.
Squad in full:
Goalkeepers: Manuel Neuer (Bayern Munich, Roman Weidenfeller (Borussia Dortmund)
Defenders: Jerome Boateng, Philipp Lahm (Bayern Munich), Matthias Ginter (Freiburg), Kevin Grosskreutz, Marcel Schmelzer (Borussia Dortmund), Marcell Jansen (Hamburg), Shkodran Mustafi (Sampdoria), Per Mertesacker (Arsenal)
Midfielders: Lars Bender (Bayer Leverkusen), Andre Hahn (Augsburg), Mario Gotze, Toni Kroos, Bastian Schweinsteiger (Bayern Munich), Mesut Ozil, (Arsenal), Sidney Sam (Bayer Leverkusen)
Attackers: Pierre-Michel Lasogga (Hamburg), Miroslav Klose (Lazio), Lukas Podolski (Arsenal), Andre Schurrle (Chelsea)