The Dortmund boss believes his team's experience of coping without key players will come in useful after the forward became the latest player to pick up a knock
BVB have had to cope without the likes of Mats Hummels, Neven Subotic, Marcel Schmelzer, Jakub Blaszczykowski and Ilkay Gundogan for much of the season.
Reus and Sven Bender picked up fresh knocks during Saturday's 5-1 win over Werder Bremen but Klopp believes his side's experiences this term will help them cope.
"The good thing about this situation is that we have learned to deal with it," he said at a press conference ahead of the DFB-Pokal trip to Eintracht Frankfurt.
Looking ahead to the match at the Commerzbank Arena, the 46-year-old said he was under no illusions as to what he can expect from Armin Veh's side.
"It's a high hurdle. They play good football. We've been drawn against a strong opponent who will demand everything from us.
"It's a final so we can reach the semi-finals."
Dortmund and Eintracht Frankfurt kick off at 20:45CET on Tuesday.